Laboratory of Analytical Biochemistry and Metabolomics (Martin Moos)
For more details and up-to-date information, please visit our website: www.bclab.eu
Our research is primarily aimed at uncovering biochemical mechanisms underlying organismal responses to environmental and physiological challenges. We are a research group focused on developing and applying advanced bioanalytical methods to study metabolism across a broad range of organisms – from insects and cyanobacteria to plants and humans – with particular emphasis on polar metabolites, hormones, bioactive peptides, and volatile organic compounds.
We operate a broad range of analytical platforms for targeted and untargeted metabolomics, lipidomics, fluxomics, and related analyses, based on LC-MS and GC-MS technologies. These platforms support both our in-house research and collaborative projects within the interdisciplinary environment of the Biology Centre. LABM contributes to high-impact publications and translates its expertise into applied outputs. These include analytical kits, protocols, and workflows for broader scientific use. A flagship example is the MetAmino® kit for amino acid analysis, developed by LABM and marketed in collaboration with Chromservis (Prague, Czech Republic).
The group is led by Martin Moos and currently consists of 15 researchers and technical staff. We actively collaborate with national and international partners on research projects that benefit from our bioanalytical expertise and methodological innovation.
Research projects
A complete list and descriptions of our ongoing and past projects are available on our website.
Research projects
New approaches to metabolite profiling in biological samples of animal origin
Multicomplex analysis of low molecular weight substances of diagnostic value has been a challenge in current metabolite research. This approach is promissing to getting an overview of the metabolic status and global biochemical events associated with a cellular or biological system. Our research aims are focused on high-end sample preparation and separaration procedures enabling comprehensive profiling of diagnostic compounds in complex biological, industrial and environmental matrices. Design and investigation of novel haloformates and their implementation in rapid, fast and reproducible analytical protocols have result in a comprehensive portfolio of unique analytical methods for a wide range of compound classes involving polyols, lipids, amines, organic acids, small peptides and steroids. The developed analytical protocols have been integrated with a house-made Metabolite Mapper tool enabling automated peak detection, metabolite library searching, component matrix formation and data exports for further data mining and statistical processing.
