Dr. Alexander W. Bruce, Ph.D.

Funkce: Bývalý zaměstnanec - Laboratoř vývojové genetiky

Kontaktní údaje

Telefon: 420387772270
E-mail: awbruce@prf.jcu.cz

Popis

1. První determinace buněčného osudu během pre-implantačního vývoje myši
- Geny důležité pro rozhodování buněčného osudu u raného embrya
- Rovnováha mezi diferenciací subpopulace buněk a udržováním pluripotence ostatních buněk
 

Publikace
Celkem nalezeno: 20 záznamů
Mihajlović A., Bruce A. W. (2016) Rho-associated protein kinase regulates subcellular localisation of Angiomotin and Hippo-signalling during preimplantation mouse embryo development. Reproductive BioMedicine Online 33 : 381-390.
DOI: 10.1016/j.rbmo.2016.06.028
Thamodaran V., Bruce A. W. (2016) p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development. Open Biology 6 : article number 160190.
DOI: 10.1098/rsob.160190
Mihajlović A., Thamodaran V., Bruce A. W. (2015) The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent. Scientific Reports 5 : article no. 15034.
DOI: 10.1038/srep15034
Mihajlović A., Thamodaran V., Bruce A. W. (2015) The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent. Scientific Reports 5 : article number 15034.
DOI: 10.1038/srep15034
Bruce A. W. (2013) Generating different genetic expression patterns in the early embryo: insights from the mouse model Reproductive BioMedicine Online 27 : 586-592.
DOI: 10.1016/j.rbmo.2013.03.024
Bruce A. W. (2011) What is the role of maternally provided Cdx2 mRNA in early mouse embryogenesis? Reprod. Biomed. Online 22 : 512-515.
DOI: 10.1016/j.rbmo.2011.02.003
Bruce A. W. (2011) Response: Role of mouse maternal Cdx2: what's the debate all about? Reprod. Biomed. Online. 22 : 519-520.
DOI: 10.1016/j.rbmo.2011.02.002
Bruce A. W., Zernicka-Goetz M. (2010) Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate. Curr. Opin. Genet. Dev. 20 : 485-491.
DOI: 10.1016/j.gde.2010.05.006
Dhami P., Bruce A. W., Jim J., Dillon S., Hall A., Cooper J., Bonhoure N., Chiang K., Ellis P., Langford C., Andrews R., Vetrie D. (2010) Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS One 5 : e9059.
Dhami P., Saffrey P., Bruce A. W., Dillon S., Chiang K., Bonhoure N., Koch C., Bye J., James K., Foad N., Ellis P., Watkins N. (2010) Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS One 5 : e12339.
DOI: 10.1371/journal.pone.0012339
Jedrusik A., Bruce A. W., Tan M., Leong D., Skamagki M., Yao M., Zernicka-Goetz M. (2010) Maternally and zygotically provided Cdx2 have novel and critical roles for early development of the mouse embryo. Dev. Biol. 344 : 66-78.
Bruce A. W., Lopez-Contreras A., Flicek P., Down T., Dhami P., Dillon S., Koch C., Langford C., Dunham I., Andrews R., Vetrie D. (2009) Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Res. 19 : 994-1005.
Wu Q., Bruce A. W., Jedrusik A., Ellis P., Andrews R., Langford C., Glover D., Zernicka-Goetz M. (2009) CARM1 is required in ES cells to maintain pluripotency and resist differentiation. Stem Cells 27 : 2637-2645.
Zernicka-Goetz M., Morris S., Bruce A. W. (2009) Making a firm decision: Transcriptional regulation of cell fate in preimplantation development. Nat. Rev. Genet. 10 : 467-477.
Bruce A. W. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 446 : 799-816.
Koch C., Andrews R., Flicek P., Dillon S., Karaoz U., Clelland G., Wilcox S., Beare D., Fowler J., Couttet P., James K., Lefebvre G., Bruce A. W. (2007) The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res. 17 : 691-707.
Bruce A. W., Ooi L., Krejčí A., Deuchars J., Wood I., Doležal V., Buckley N. (2006) The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype. J. Neurochem. 98 : 1828-1840.
Follows G., Dhami P., Göttgens B., Bruce A. W., Campbell P., Dillon S., Smith A., Koch C., Donaldson I., Scott M., Dunham I., Janes M., Vetrie D., Green A. (2006) Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites. Genome Res. 16 : 1310-1319.
Johnson R., Gamblin R., Ooi L., Bruce A. W., Donaldson I., Westhead D., Wood I., Jackson R., Buckley N. (2006) Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication. Nucleic Acids Res. 34 : 3862-3877.
Bruce A. W., Krejčí A., Doležal V., Tuček S., Buckley N. (2004) Multiple promoters drive tissue-specific expression of the human M muscarinic acetylcholine receptor gene. J Neurochem. 91 : 88-98.

KONTAKT

Biologické centrum AV ČR, v.v.i.
Entomologický ústav
Branišovská 1160/31
370 05 České Budějovice

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